Our efforts to respond to climate and biosphere disruption are part of the long game, a game that must be played over centuries, rather than decades. The so-called normal climate of the 20th century, which we use as our meteorological baseline, is gone forever. The Earth will not see such a climate again for millennia, if ever. The stark reality of our situation means that everything we do now is for the benefit of future generations that will occupy a massively transformed planet. Our target for building a sustainable civilization should be 2100 and beyond. In the face of progressive disruptions of the climate and biosphere and the associated losses and hardships, we must lay the foundation for a civilization capable of thriving under conditions never before seen in our evolutionary history.